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Selective small molecule ALDH2 activators have been reported to accelerate acetaldehyde clearance in mice and to alleviate liver steatosis and cell apoptosis

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In this anabolic process, the upregulation of renal insulin-like growth factor 1 (IGF-1) plays a key role, which has inspired numerous studies considering the potential regenerative actions of the IGF-1 and the subsequent increase in the glomerular filtration rate